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Effect of Vasopressin and Pyrogen

Bernard Schwartz, MD, PhD; Michael A. Golden, MD; Robert A. Wiznia, MD; Steven A. Miller, MD

Arch Ophthalmol. 1981;99(10):1770-1777.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

• Various types of glaucomatous and normal subjects were tested for the adequacy of the stress response of their hypothalamic-pituitary-adrenal axis to pyrogen and vasopressin. With pyrogen, a significant response of elevation of plasma cortisol levels was positively correlated with ocular pressure and changes of the optic disc. Those subjects with increased ocular pressure and optic disc cupping and pallor had greater rises of plasma cortisol levels. With vasopressin, a decreased response of plasma cortisol levels was negatively correlated with the degree of elevated ocular pressure. Those subjects with increased ocular pressure and lower tonographic outflow facilities had smaller rises of plasma cortisol levels. Both tests indicated a disturbance of the hypothalamic-pituitary-adrenal axis in subjects with glaucoma. The enhanced response to pyrogen was interpreted as being caused by increased levels of pituitary adrenocorticotropic hormone in subjects with glaucoma. The impairment of the vasopressin response was interpreted as being caused by . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Ophthalmology, Tufts University School of Medicine and New England Medical Center Hospital, Boston.

Footnotes
Accepted for publication Oct 4, 1980.

Read in part before the annual meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 1, 1978.

Reprint requests to Department of Ophthalmology, New England Medical Center Hospital, 171 Harrison Ave, Boston, MA 02111 (Dr Schwartz).

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