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Anatomy, Histology, and Electron Microscopy

ARNOLD J. KROLL, MD; TOICHIRO KUWABARA, MD

Arch Ophthalmol. 1966;76(2):244-257.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The ocular myopathy associated with dysthyroid¹ (endocrine) exophthalmos remains an intriguing problem. The gross and histologic findings are well-known.^2-7 Grossly, the extraocular muscles are firm, rubbery, and very much enlarged. Histologically, there is interstitial edema, round cell infiltration, and, in some cases, degenerative change within muscle cells. Similar changes are found in the orbital tissues in experimentally produced exophthalmos in guinea pigs.^6,8-15 The edema is believed to be due to an increased content of waterbinding mucopolysaccharide, probably hyaluronic acid.^16-18 The round cell infiltrate in animals and man includes lymphocytes, plasma cells, macrophages, and mast cells.^16,18-20

The fine structure characteristics of extraocular muscle in dysthyroid exophthalmos have not yet been reported.

Materials and Methods

Biopsy material was obtained at the time of Krönlein orbital decompression from 19 mucles of 17 eyes of ten patients with dysthyroid exophthalmos³⁷ (Table). The patients' ages ranged from 41 to . . . [Full Text PDF of this Article]

Author Affiliations
Miami, Fla; Boston

From the Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary, Boston. Dr. Kroll is now at the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Fla.

Footnotes
Submitted for publication Dec 8, 1965.

Reprint requests to Bascom Palmer Eye Institute, 1638 NW 10th Ave, Miami, Fla 33136 (Dr. Kroll).

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