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JAMES B. WISE, MD

Arch Ophthalmol. 1966;75(5):698-707.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The retention of an iron foreign body within an eye almost always results in progressive iron deposition throughout the eye, cataract formation, glaucoma, and eventually atrophy of all the intraocular tissues. This condition is known as siderosis bulbi.¹ To prevent it, any intraocular iron particle must be removed surgically, if possible, even if the surgery itself may result in loss of the eye. Once siderosis is established, surgery seldom helps.² Furthermore, as in two patients seen at the Wilmer Clinic recently, small iron particles may oxidize to nonmagnetic rust which cannot be localized or surgically extracted.

Medical therapy of siderosis has been attempted using galvanic deactivation,³ intravenous edetic acid,^4,5 and subconjunctival edetic acid or adenosine triphosphate.^6,7 Edetic acid (formerly known as edathamil), the principal agent studied, has shown a number of toxic effects in humans receiving chronic systemic therapy.^8,9

In 1960, Bickel et al . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Wilmer Institute of Ophthalmology, Johns Hopkins Hospital and Johns Hopkins University, Baltimore.

Footnotes
Submitted for publication Oct 13, 1965.

Reprint requests to 1211 N Shartel, Oklahoma City, Okla 73103, after July 1, 1966.

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