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I. Topical Administration of Dexamethasone

C. SHORT, DVM; R. H. KEATES, MD; E. F. DONOVAN, DVM; M. WYMAN, DVM; P. W. MURDICK, DVM

Arch Ophthalmol. 1966;75(5):689-692.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Dexamethasone is a corticosteroid which was introduced to ophthalmology in 1958.¹ The indications for its use are similar to those for other corticosteroid preparations.

The synthesis of dexamethasone was achieved by addition of a methyl radical at carbon 16 and a flourine atom at carbon 9 of the prednisolone structure. Initial studies revealed that this compound has a milligram activity approximately ten times that of prednisone or prednisolone and 30 times that of cortisone.²

The success of therapy with dexamethasone or other steroids in indicated cases depends on the frequency of administration, the proper route, a sufficient dose level, and a long enough duration of therapy.

Dosage concentrations and frequencies are often based on empirical impressions of clinical effectiveness. Determination of local steroid concentration at the intended site of action should help formulate a more objective method of dosing. Attempts to do this have been based, until recently, . . . [Full Text PDF of this Article]

Author Affiliations
Columbus, Ohio

From the Department of Ophthalmology, College of Medicine, and Department of Veterinary Medicine, College of Veterinary Medicine, Ohio State University, Columbus.

Footnotes
Submitted for publication Nov 1, 1965.

Reprint requests to University Hospital, 410 W 10th Ave, Columbus, Ohio 43210 (Dr. Keates).

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