This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CLYDE L. OLSON, MD

Arch Ophthalmol. 1966;75(5):651-658.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Much attention has been given to the clinical and pathological events which occur following the injection of antigenic substances into rabbit cornea.^1-6 Within five days following injection, conjunctival and limbal hyperemia develop, followed by diffuse corneal clouding. Histopathologically, the cornea shows edema and infiltration by lymphocytes and mononuclear cells. This tissue reaction has been shown to be a manifestation of delayed-type hypersensitivity according to the following criteria: the lack of circulating antibody, a delayed-type skin hypersensitivity to specific antigen, and the ability to passively transfer this tissue hypersensitivity only with whole lymphoid cells from the sensitized animal.

The initial conjunctival inflammation and corneal clouding disappear within one week, leaving a clinically normal eye. Between 12 and 18 days after injection, however, marked local inflammatory signs return, accompanied by corneal neovascularization and corneal clouding; and, depending on the dose of antigen initially injected, a white ring (Wessely ring) appears in . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Wilmer Ophthalmological Institute, Baltimore.

Footnotes
Submitted for publication June 23, 1965.

Reprint requests to US Naval Hospital, Key West, Fla 33040 (Lt Olson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?