This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DOUGLAS L. JOHNSON, MD; LESLIE W. JACOBSON, MD; ROY TOYAMA, MD; ROBERT H. MONAHAN, MD

Arch Ophthalmol. 1966;75(1):84-88.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chediak-Higashi syndrome usually occurs in albinoid siblings born of consanguinous parents. It is characterized by a lymphomatous development and multiple infections resulting in early death. Typical cytoplasmic inclusion bodies are present in many of the leukocytes throughout the body. For the first time the presence of these inclusion bodies within the globe is being shown.

History of the Concept

The concept of the Chediak-Higashi syndrome was outlined by Sato¹ in 1955. After reviewing Chediak's² report of an involved family in Cuba in 1952 and Higashi's³ paper on a similar family involvement in Japan, published in 1954, Sato, in the Tohoku Journal of Experimental Medicine suggested the name of the syndrome. He also listed its characteristic features as albinism, photophobia, early death of albinotic siblings, and characteristic (possibly pathognomonic) blood morphology. Sato concluded that the patient succumbs invariably to acute infection at an early age (1 to 6 . . . [Full Text PDF of this Article]

Author Affiliations
Minneapolis

From the Department of Ophthalmology, College of Medical Sciences, University of Minnesota, Minneapolis.

Footnotes
Submitted for publication June 1, 1965.

Reprint requests to Department of Ophthalmology, University of Minnesota, College of Medical Sciences, Minneapolis 55414 (Dr. Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?