This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (43)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MORTON E. SMITH, MD; LORENZ E. ZIMMERMAN, MD

Arch Ophthalmol. 1966;75(1):42-51.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Amyloidosis may be considered a group of disorders of diverse etiology and pathogenesis that have in common certain characteristic histopathologic features. Their essential unifying characteristic is the deposition in various tissues of a hyaline substance that can be distinguished from other types of hyalin by use of appropriate histopathologic technics. The exact nature of amyloid remains to be determined, however, and, in fact, there is reason for believing that amyloid deposits vary in composition sufficiently to form a spectrum from typical amyloid to nonspecific hyalin. The term "paramyloid" has been introduced to designate hyaline deposits that give atypical or inconsistent staining reactions for amyloid.

Several recent publications^1-6 have reviewed the various concepts of the nature and pathogenesis of amyloidosis, but the clinicopathologic classification offered by Reimann and co-workers⁷ 30 years ago continues to enjoy general acceptance:

1. Primary amyloidosis, in which there is no known predisposing disease, characterized
   

Author Affiliations
Washington, DC

From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20305.; Work was done during tenure of a Special Fellowship in Ophthalmic Pathology of the National Institute of Neurological Diseases and Blindness, NIH, at the Armed Forces Institute of Pathology (Dr. Smith). Present address: Department of Ophthalmology Washington University School of Medicine, St. Louis, Mo 63110. Chief, Ophthalmic Pathology Branch, Armed Forces Institute of Pathology (Dr. Zimmerman).

Footnotes
Submitted for publication May 10, 1965.

Reprint requests to Armed Forces Institute of Pathology, Washington, DC 20305.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?