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The Corneal Tuberculin ReactionEffect of Systemic Desensitization Treatment
JOHN E. MILNER, MD;
RUSSELL S. WEISER, PhD
Arch Ophthalmol. 1965;74(6):845-846.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Phlyctenular keratoconjunctivitis is a rare manifestation of tuberculosis. If the disease is acute, local corticosteroid therapy coupled with systemic antituberculous drugs commonly results in a speedy cure. However, in chronic or recurrent disease, therapy is less effective. In such cases, antituberculous drugs alone are usually ineffectual, and supplementation with topical corticosteroids may have only a temporary suppressive effect.
It is generally believed that the phlyctenules of phlyctenular keratoconjunctivitis represent mainly an allergic response to tuberculoprotein.1 Desensitization treatment with tuberculin has been used successfully for adjunctive therapy in certain carefully selected cases in which the usual agents, such as topical steroids and systemic antibiotics, were ineffective.2,3 Pines3 has reported that systemic corticosteroid therapy facilitates rapid desensitization with tuberculin.
Since no experimental evidence has been gained in animals or in man that tuberculin treatment sufficient to effectively abolish skin reactivity will at the same time abolish corneal reactivity, the
. . . [Full Text PDF of this Article]
Author Affiliations
Seattle
From the Department of Microbiology, School of Medicine, University of Washington, Seattle.
Footnotes
Submitted for publication June 8, 1965.
Reprint requests to Department of Microbiology, Univerversity of Washington, School of Medicine, Seattle, Wash 98105 (Dr. Milner).
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