This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (63)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

J. R. SIDDALL, MD, FRCS, FACS

Arch Ophthalmol. 1965;74(4):460-464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Prolonged chlorpromazine therapy has been used extensively in the Provincial Mental Institution, at Essondale, BC, since 1956. The first toxic manifestation of grey-purple pigmentation of the skin was noted in 1958. Ocular toxic effects on 12 patients, involving lens and cornea were reported by Greiner and Berry¹ in a series of 21 patients.

In Jan and Feb, 1964, 78 patients were examined of which 50 were on chlorpromazine. These latter form the substance of this review. Twenty-eight were excluded because they had taken other phenothiazine derivatives as well as chlorpromazine, but they exhibited the same ocular findings as those on chlorpromazine alone. Of the patients, 34 were women and 16 men, and they ranged in age from 17 to 70 years (mean age 41 years). Examination was especially directed to the pigmentation of the skin of the face, lids, and the conjunctiva. Biomicroscopy was performed on cornea, iris, and . . . [Full Text PDF of this Article]

Author Affiliations
Burnaby, British Columbia

Footnotes
Submitted for publication March 1, 1965.

Reprint requests to 4900 Kingsway, South Burnaby, British Columbia, Canada.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?