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ELIOT L. BERSON, MD; GEORGE S. KOBAYASHI, PhD; RICHARD B. OGLESBY, MD

Arch Ophthalmol. 1965;74(3):403-411.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several excellent reviews^{10,11,26,39,42} and case reports^4,5,21,24,27 have emphasized the difficulty in treatment of mycotic keratitis and the aggravating effects of some antibiotics^20,33,41 and steroids^1,4,20,28,40 on these infections. The various forms of chemotherapy have included amphotericin B with debridement,^4,5,13 30% sodium sulfacetamide solution by iontophoresis,¹³ 1:1,000 Merthiolate ophthalmic ointment,¹³ nystatin topically,^9,31 local cycloheximide,²³ and oral sodium iodide with local 0.125% copper sulfate and tincture of iodine.^2,6 Poor intraocular penetration²⁹ and local toxicity¹ of the suggested drugs have hampered interpretation of chemotherapy. Physical measures suggested for treatment have included ultraviolet phototherapy,⁷ thermophore,² and excision with keratoplasty.⁴² Human clinical experience has been difficult to evaluate because the stage of the disease at the time of treatment has varied and the fungus has differed from case to case. The number of cases reported by any single study has been . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine. Department of Ophthalmology (Dr. Berson and Dr. Oglesby); Department of Internal Medicine, Division of Dermatology (Dr. Kobayashi).

Footnotes
Submitted for publication April 24, 1965.

Reprint requests to Department of Ophthalmology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, Mo 63110 (Dr. Berson).

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