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A Report of Laboratory Studies and a Case Report of Postsurgical Cephalosporium Endophthalmitis

WILLIAM R. GREEN, MD; JOHN E. BENNETT, MD; ROGER D. GOOS, PhD

Arch Ophthalmol. 1965;73(6):769-775.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Amphotericin B is well established as a fungistatic agent¹ that is effective in the treatment of several systemic mycotic infections.² Experience with its use in fungus diseases of the eye, though apparently beneficial, has been limited.^3-6 Two reports have been found in which amphotericin B was used in the treatment of postoperative mycotic intraocular infections.^5,6

Whether amphotericin B penetrates the eye is unknown. Previous attempts to demonstrate such penetrations have been unsuccessful,³ and it has been stated that amphotericin B cannot be identified in intraocular fluids following parenteral administration.⁴

Recently a patient with postoperative mycotic endophthalmitis was observed in whom the use of intravenous amphotericin B resulted in a dramatic response with clearing of the infection. The clinical observation prompted laboratory studies of the intraocular penetration of amphotericin B in rabbits under experimental conditions.

Case Report

A 75-year-old white woman was first found . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness (Dr. Green), the Laboratory of Clinical Investigations (Dr. Bennett), and the Laboratory of Infectious Diseases (Dr. Goos), National Institute of Allergy and Infectious Diseases, National Institutes of Health, US Public Health Service, Department of Health, Education and Welfare, Bethesda, Md.

Footnotes
Submitted for publication Sept 19, 1964.

Reprint requests to National Institute of Neurological Diseases and Blindness, Bethesda 20014 (Dr. Green).

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