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A Sequential Double-Blind Controlled Study

DANIEL R. L. HART, FRCS, FRACS; VERNON J. F. BRIGHTMAN, MDSc, PhD; GRAHAM G. READSHAW, MB, BS; GEOFFREY T. J. PORTER, MB, BS; MARY J. TULLY, BSc

Arch Ophthalmol. 1965;73(5):623-634.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The original report of Kaufman et al,¹ describing treatment of human herpes simplex keratitis with idoxuridine (5-iodo-2'-deoxyuridine, IDU) was followed by a series of publications by other workers which provided further evaluation of this drug. The majority of these publications, which were reviewed in an earlier paper,² described uncontrolled trials, but three reports^3-5 were concerned with studies which included controls in their evaluation of the effect of idoxuridine on herpetic keratitis. The uncontrolled trials largely confirmed the results of Kaufman et al, but the three studies which included controls were unable to show that treatment with idoxuridine was remarkably better than treatment with inert eye drops: Luntz and MacCallum,³ in an open trial comparing idoxuridine with neomycin, treated 11 cases of dendritic ulcer with idoxuridine and 11 cases with neomycin and were unable to find any striking advantage for idoxuridine. In two double-blind controlled series, . . . [Full Text PDF of this Article]

Author Affiliations
Brisbane, Australia

From the Princess Alexandra Hospital and Department of Microbiology, University of Queensland, Brisbane, Australia.

Footnotes
Submitted for publication Sept 8, 1964.

Reprint requests to Department of Dental Research, Philadelphia General Hospital, 34th St and Curie Ave, Philadelphia, Pa 19104 (Dr. Brightman); or 137 Wickham Terrace, Brisbane, Australia (Dr. Hart).

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