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Antimetabolite Suppression of Corneal Hypersensitivity
HOWARD M. LEIBOWITZ, MD;
JAMES H. ELLIOTT, MD
Arch Ophthalmol. 1965;73(1):94-111.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The corneal homograft reaction, like the rejection of other homotransplanted tissues and organs, is an immune response of the host to the donor cornea. The precise nature of this immune response, however, is not entirely clear.
At the risk of oversimplification, it is useful to divide all immunological reactions into two classes. The first includes all states of hypersensitivity which seem to have their basis in immunologically competent, bloodborne, mononuclear cells. This group of immune phenomena is referred to as delayed hypersensitivity. The second general class of immunological reactions is mediated by circulating humoral antibodies; this group is referred to as immediate hypersensitivity.
We may assume, therefore, that the homograft reaction in the cornea or elsewhere has one of three etiologic mechanisms. First, the antigen of the graft may stimulate the production of immunologically competent lymphoid cells which, in turn, leave their site of origin and enter the grafted foreign
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary and the Department of Ophthalmology, Harvard Medical School.
Footnotes
Submitted for publication May 22, 1964.
This investigation was supported (in part) by a United States Public Health Service Grant 5T1 NB 5142-07 (Dr. Leibowitz) and Special Fellowship 1 Fll 1194-01 (Dr. Elliott).
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