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HARRY MAISEL, MD

Arch Ophthalmol. 1964;72(6):829-831.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Uhlenhuth (1903)¹ was the first to recognize that lens proteins of all vertebrate classes share some common antigenic groups. This property of lens tissue is referred to as organ specificity. For many other tissues, however, species specificity predominates and cross-reactions occur only among closely related animals.

Of the different lens proteins -crystallin is generally regarded as showing the greatest degree of organ specificity.^2,3 Furthermore, the immunoelectrophoretic studies of Manski et al,⁴ using anti-human cataract serum, revealed that the decreasing number of cross-reactions with nonmammalian lenses involved only the β- and -crystallins, except in the case of fish where it involved -crystallin as well. The latter observation suggests that -crystallin has undergone some change during evolution.

The data reported in this study using antisera specific for lens -crystallin will show that this conservative protein has indeed been modified at each class level of the phylogenetic scale.

Materials and . . . [Full Text PDF of this Article]

Author Affiliations
Detroit

Wayne State University School of Medicine.

Footnotes
Submitted for publication May 20, 1964.

Supported by grants GM-10634 from the United States Public Health Service and by grant G-261 National Council to Combat Blindness, New York.

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