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J. LITTLE, MD; J. LANGMAN, MD, PhD

Arch Ophthalmol. 1964;72(6):820-825.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In 1959, Langman and Prescott¹ were able to demonstrate by means of immunological techniques^2,3 that the iris, retina, and cornea of the adult chick contain a number of antigenic components identical to those of the lens. These observations were later confirmed by Maisel and Langman,^4,5 who subsequently succeeded in showing that some of the iris and retina antigens were identical to -, β-, and -crystallin, the three main soluble proteins of the lens. Recently, Maisel and Harmison^6,7 found that one of the iris proteins is not only antigenically identical to -crystallin of the lens but also has an electrophoretic mobility and sedimentation coefficient of approximately the same value.

Further proof for the presence of lens antigens in the intraocular tissues was found when chick embryos (approximately 32 hours—lens induction stage) were treated with antibodies prepared against isolated crystallin.^8,9 The degeneration and abnormalities of the . . . [Full Text PDF of this Article]

Author Affiliations
Montreal

From the Department of Anatomy, McGill University.

Footnotes
Submitted for publication May 6, 1964.

This investigation was supported by grants (B3245 and NB 03245-02 and 03) from the National Institutes of Health, United States Public Health Service and from the Medical Research Council of Canada.

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