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BERNARD BECKER, MD

Arch Ophthalmol. 1964;72(6):769-771.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Elevations of intraocular pressure and decreases in outflow facility have been reported after the topical administration of glucocorticoids.^1-6 Marked changes have been observed in patients with proved primary openangle glaucoma, but remarkable elevations of pressure have also been noted in the families of glaucoma patients as well as in some apparently "normal" individuals. The working hypothesis was formulated that the intraocular response to topical corticosteroids was genetically determined and transmitted as a monogenic dominant.⁷ An alternative suggestion was that the glaucomatous eye, with its damaged outflow channels, responded more dramatically than the normal eye to the effects of steroids and related pharmacologic agents.⁵ One method for testing these alternate hypotheses would be to evaluate the effects of topical corticosteroids on eyes with secondary glaucomas. Since the marked response occurred in almost all eyes with primary open-angle glaucoma but only in about 35% of "normal" volunteers, such a . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis, Mo

From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Footnotes
Submitted for publication March 14, 1964.

This study was supported in part by a research grant (B-621) from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Md.

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