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FRANK L. SEEGER, MD; PHILIP MERIWETHER LEWIS, MD

Arch Ophthalmol. 1964;72(2):219-224.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Mannitol is the reduced form of the sixcarbon sugar mannose, and is essentially unmetabolized, limited to the extracellular space, freely filtered by the glomeruli, and neither reabsorbed nor actively excreted by the renal tubules^1,7,9,10; thus it has been useful as an osmotic diuretic as well as in the measurement of glomerular filtration rate.^3,7 It has recently been used as a hypertonic intravenous solution for the osmotic reduction of intraocular pressure.^1,11,12 It is chemically stable and can be stored in solution at room temperature ready for use.

Its ocular hypotensive effect has been used in many ophthalmic conditions, such as acute angle-closure glaucoma, chronic open-angle glaucoma, many forms of secondary glaucoma, and in glaucomatous and nonglaucomatous patients prior to intraocular surgery in order that the eye will be normotensive or even hypotensive at the time of surgery.^1,11,12 The hypotensive effect (on cerebrospinal fluid pressure) has been . . . [Full Text PDF of this Article]

Author Affiliations
Memphis

From the Department of Ophthalmology, University of Tennessee College of Medicine; City of Memphis Hospitals; and the Memphis Eye, Ear, Nose, and Throat Hospital.

Footnotes
Read before the Tennessee Academy of Ophthalmology and Otolaryngology, April 13-14, 1964.

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