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Retinal Involvement in Adult Cytomegalic Inclusion Disease
MORTON E. SMITH, MD
Arch Ophthalmol. 1964;72(1):44-49.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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In recent years, increasing attention has been given to the clinical entity known as cytomegalic inclusion disease or generalized salivary gland virus disease. This multisystem viral disease is characterized histologically by the peculiar giant cells with intranuclear and cytoplasmic inclusions.1 The disease is primarily of interest to the pediatrician since it occurs most commonly in the newborn and is manifested by prematurity, jaundice, thrombocytopenia, anemia, hepatosplenomegaly, and neurological involvement.2 In addition, these affected infants frequently have chorioretinitis, and the disease therefore becomes of particular interest to the ophthalmologist as well.3-6 Because of the chorioretinal findings and the frequent finding of intracranial calcification, clinical differentiation from toxoplasmosis is difficult.3 Besides the generalized form in the newborn, it has been reported that the inclusions occur in the salivary glands of 8% to 32% of infants and young children who die from various causes.7
The disease in the
. . . [Full Text PDF of this Article]
Author Affiliations
St. Louis
Present address until January, 1965: Ophthalmic Pathology Branch, Armed Forces Institute of Pathology, Washington, DC 20025.; From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.
Footnotes
Submitted for publication Dec 12, 1963.
This work was supported in part by research grant NB-D1789 from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, United States Public Health Service.
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