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AUSTIN I. FINK, MD; MIDORIKO TSUNEMATSU, MD; DAVID KAPLAN, MD

Arch Ophthalmol. 1964;71(6):787-792.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Cryoglobulins are groups of cold-precipitable proteins greatly resembling normal -globulin,¹ and their most striking characteristic is their ability to precipitate when exposed to a lowered temperature. An essential part of the phenomenon relates to the precipitate returning to solution when the temperature is raised to 37 C. The most prominent symptom noted in this disease is a particular sensitivity to lowered temperature with oronasal bleeding a common finding.² Physical findings include weight loss, pallor, petechiae with purpura, mottling and occasional ulceration of the lower extremity. The ocular findings include slowing and stasis of blood flow with marked erythrocytic aggregations in the vessels of the bulbar conjunctiva.³ Ophthalmoscopic study has demonstrated dilated retinal veins with slowing and segmentation as well as occasional retinal hemorrhages and exudates.⁴

In 1957 Harders⁵ reported observations on conjunctival blood flow in a patient with Waldenström's macroglobulinemia who in addition . . . [Full Text PDF of this Article]

Author Affiliations
Brooklyn, NY

From The Division of Ophthalmology, Department of Surgery (Dr. Fink, Dr. Tsunematsu) and the Department of Medicine (Dr. Kaplan), State University of New York Downstate Medical Center.

Footnotes
Presented at the Eastern Section Meeting of the Association for Research in Ophthalmology, Brooklyn, NY, March 8, 1963.

Supported by grant H 06935-02 from the Hematology Division, National Heart Institute, National Institutes of Health.

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