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Leon Jacobs, PhD
Chief Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases Bethesda, Md 20014

Arch Ophthalmol. 1964;71(5):757-759.

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To the Editor:

The editorial of Dr. Hogan in the January, 1964, issue of the ARCHIVES (71:1-3, 1964), discussing papers on experimental chemotherapy of ocular toxoplasmosis, contains what I consider a number of misinterpretations.

1. Dr. Hogan states that the experimental model is questionable, because the uveitis induced was anterior, not posterior. The blood supply is different anatomically, but is it certain that there are differences in the diffusibility of substances across the membranes in different areas? Wolff says "the double vascular supply of the retina brings it into line with the double supply to the brain, namely a cortical and basal system of vessels which do not anastomose. The choroid may be regarded as the forward continuation of the pia arachnoid." Is it illogical to expect that if drugs can affect Toxoplasma in the extraneural viscera and brain they can do so in the eye? The anterior disease allows for
   

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