This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (31)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

FRANK M. POLACK, MD; JEANNETTE ROSE, BS

Arch Ophthalmol. 1964;71(4):520-527.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The antimetabolic activity of 5-iodo-2'-deoxyuridine (IDU) and its effectiveness in the treatment of herpetic keratitis has been reported at length,^1-7 the consensus being that this antimetabolite is effective in most cases of superficial herpes of the cornea. When IDU is used in therapeutic doses it does not seem to harm the normal cornea, although the possibility of inhibition of desoxyribonucleic acid (DNA) synthesis by corneal cells,⁸ and of cellular reproduction⁹ has been mentioned.

Delamore and Prussoff believe that the mechanism of action of IDU varies in different types of cells in vitro.¹⁰ For example in mammalian cells IDU can inhibit the formation of thymidine by blocking the formation of orotic and thymidillic acid, precursors of thymidine.¹¹ In the case of herpes virus, IDU can compete with each enzymatic step in the modification and incorporation of thymidine into DNA. This will cause a halt either . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Ophthalmology Research, Columbia University, College of Physicians and Surgeons, and the Corneal Unit of the Institute of Ophthalmology, Presbyterian Hospital.; Special Fellow National Institutes of Health (BT-819) (Dr. Polack).

Footnotes
Submitted for publication Sept 26, 1963.

This investigation was supported in part by an Nonr Contract 266 (71) and in part by a research grant B 492 (CIO) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?