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Use of Nitrate and Nitrite Vasodilators by Glaucomatous Patients
CLAIBORNE G. WHITWORTH, MD;
W. MORTON GRANT, MD
Arch Ophthalmol. 1964;71(4):492-496.
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There is a legend in textbooks of pharmacology and therapeutics that glaucomatous eyes may be endangered by organic nitrate or nitrite vasodilator drugs of the type employed for relief of angina pectoris.1-3 Manufacturers of these drugs give similar warnings, some going so far as to say that use of their product is contraindicated in the presence of glaucoma.
Actually, no case demonstrating precipitation of glaucoma or worsening of glaucoma by nitrate or nitrite vasodilators is to be found in the literature. The whole apprehension has been based on experiments years ago showing that intraocular pressure could be occasionally raised slightly and very briefly by inhalation of amyl nitrite. No comparable observations have been published on any of the related drugs.
Modern concepts of glaucoma mechanisms suggest that the nitrate or nitrite vasodilators should present no danger in open-angle glaucoma, but it is conceivable that in eyes anatomically predisposed to
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
Massachusetts Eye and Ear Infirmary, Boston (Glaucoma Consultation Service and Howe Laboratory of Ophthalmology).
Footnotes
Submitted for publication Sept 12, 1963.
This work was supported by grants from the Institute of Neurological Diseases and Blindness of the National Institutes of Health, United States Public Health Service (research Grant B-218), and by the Council for Research in Glaucoma and Allied Diseases, Alfred P. Sloan Foundation, Inc.
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