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Denmonstration of Lens Pathology

ROBERT D. BROWNELL, MD; J. REIMER WOLTER, MD

Arch Ophthalmol. 1964;71(4):481-483.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The lens pathology of bilateral progressive anterior lenticonus in familial hemorrhagic nephritis (Alport's syndrome) is reported in this paper. The lens pathology consists of thinning of the lens capsule, decrease of the number of lens epithelial cells, bulging of lens substance, and minimal subcapsular cataract at the anterior pole of both lenses.

Alport's syndrome has been known since 1912 as "hereditary familial congenital hemorrhagic nephritis."^1,2,3 The earliest reports of the syndrome found were by Guthrie in 1897 and 1902.^4,5 In its initial description it was thought to include only progressive nephritis with albuminuria and hematuria and progressive congenital nerve deafness. The nephritis characteristically leads to early death in males while females usually have a normal life expectancy.^2,6,7 Lens involvement with anterior lenticonus, spherophakia, anterior polar cataract, and posterior cortical cataract has later been described in association with the syndrome.⁶ It is interesting to note that lens . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich

From the Department of Ophthalmology of the University of Michigan Hospital.

Footnotes
Submitted for publication July 15, 1963.

Supported by Grant No. B-2873 of the US Department of Public Health, Education, and Welfare.

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