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JOHN F. SCHMEDTJE, PhD; BENJAMIN SPECTOR, MD

Arch Ophthalmol. 1963;70(5):666-670.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Intraocular blood vessels are highly impermeable to protein, except when local injury to tissue occurs. At such times a large volume of capillary filtrate, rich in plasma protein, leaks into the surrounding tissue.¹ In addition, any foreign protein that happens to be in the general circulation may also leak out and stimulate the production of a localized tissue hypersensitivity. For example, Seegal and Seegal² produced a mild intraocular inflammation of the rabbit eye by an intra-aqueous injection of dilute glycerine and at the same time introduced egg albumin into the general circulation. Later, an intravenous challenge dose of the same protein caused an immediate-type hypersensitivity reaction in the previously inflamed eye. Similarly, Taylor and Suie^3,4 traumatized the rabbit eye with an external mechanical blow and introduced beef albumin into the general circulation. Ten days later, an intravenous challenge dose of the same antigen revealed a state . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Department of Anatomy, Tufts University School of Medicine.

Footnotes
Submitted for publication May 7, 1963.

This work was supported by Grant NB-02334-03 from the National Institute of Neurological Diseases and Blindness.

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