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An Orally Effective Osmotic Agent

ROBERT P. THOMAS, MD

Arch Ophthalmol. 1963;70(5):625-628.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Osmotic agents, chiefly urea and mannitol, currently are widely utilized to obtain rapid and profound, albeit transient, drops in the intraocular and intracranial pressure. Ideally such an agent should be effective both orally and intravenously, since the oral route in appropriate patients would avoid the hazards associated with the introduction of hypertonic solutions directly into the vascular system. Although Javid¹ utilized urea (and effectively so) via the gastric route, the emetic and purgative effect made him consider the intravenous route preferable. Since mannitol is not absorbed from the intestinal tract, it is not effective when given by mouth.

The present investigation concerns the effect of orally administered glycerin (glycerol) on the intraocular tension in 16 glaucomatous eyes.

Methods

Glycerin (Mallinckrodt, C. P.) in various amounts diluted with orange juice to a total volume of 250 cc was given orally to uncontrolled glaucoma patients selected from the Eye Clinic . . . [Full Text PDF of this Article]

Author Affiliations
Augusta, Ga With the technical assistance of Jerry L. Long

Footnotes
Submitted for publication April 22, 1963.

This investigation was supported in part by a research grant, NB-04218-01, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, United States Public Health Service. Research relating to this study was also financed in part from a grant from the Professional Research Fund of the Medical College of Georgia.

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