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Water Permeability of the Living Cornea
ANTHONY DONN, MD;
STANLEY L. MILLER, PhD;
NANCY M. MALLETT, BS
Arch Ophthalmol. 1963;70(4):515-521.
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It has been proposed that a primary water pump across the cornea might provide the means by which the epithelial or endothelial metabolism keeps the cornea unswollen and transparent.1,2 Some data have been published which could be interpreted as evidence for a water pump acting across the endothelium.3 The cornea's permeability to water could also influence intraocular dynamics if there were a significant net transport of water into or out of the eye by active transport or by the normal hydrostatic pressure gradient.
Cogan and Kinsey measured water flux across the excised cat cornea using D2O as a tracer.4,5 No attempt was made in these studies to determine whether the corneas were alive and functioning. It is quite probable that their preparations were dead, and therefore, if an active corneal water transport exists, these corneas would not have exhibited it. Potts tried to measure the
. . . [Full Text PDF of this Article]
Author Affiliations
New York; La Jolla, Calif; New York
From the Department of Ophthalmology and the Department of Biochemistry, Columbia University, College of Physicians and Surgeons. Dr. Miller's present address is the Department of Chemistry, University of California (San Diego), La Jolla, Calif.
Footnotes
Submitted for publication Feb 11, 1963.
An abstract of this work was presented at the National Meeting of the Association for Research in Ophthalmology in June, 1961.
This investigation was supported in part by a research grant B 2343 and B 2343(C) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.
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