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BERNARD BECKER, MD; DONALD W. MILLS, MD

Arch Ophthalmol. 1963;70(4):500-507.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The finding of -globulin and plasma cells in the trabecular meshwork of glaucomatous eyes suggested an immunogenic component.^1,2 The present study was undertaken to determine, under controlled conditions, the effect of topical corticosteroids in the eye with primary open-angle glaucoma.

Corticosteroids have been incriminated in the exacerbation or production of the glaucomatous state.^3-7 Such reports were largely concerned with glaucoma occurring during the course of uveitis and were difficult to interpret. Several authors have demonstrated no effect of steroids on intraocular pressure.^8,9,10 In a controlled study of topical steroids in nurses, Linnér¹¹ noted a small but significant increase in intraocular pressure without change in outflow facility. François¹² and Goldmann¹³ have recorded glaucomatous states after prolonged topical steroid therapy, but these were considered rare occurrences. Recently Bernstein and Schwartz¹⁴ found that patients on long-term systemic corticosteroid therapy showed significantly higher mean applanation pressures . . . [Full Text PDF of this Article]

Author Affiliations
St Louis

Fellow of the R. Samuel McLaughlin Foundation of Canada (Dr. Mills).; From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Footnotes
Submitted for publication May 9, 1963.

Presented at the American Medical Association Section on Ophthalmology, Atlantic City, NJ, June, 1963.

This study was supported in part by a grant from Research to Prevent Blindness, Inc., New York, and by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Bethesda, Md.

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