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CARL KUPFER, MD

Arch Ophthalmol. 1963;70(2):256-260.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Although sectioning of the optic nerve close to the eye results in chromatolysis¹ and eventual degeneration^2,3 of the retinal ganglion cell, interruption of the optic nerve fibers farther from the eye at the level of the chiasm has failed to produce easily perceptible changes in the ganglion cells of rabbit, cat, and monkey.^4,5 These findings have lent support to the concept that chromatolytic and degenerative changes in the retinal ganglion cell are inversely proportional to the distance of the injury from the cell body, a concept generally accepted for ganglion cells elsewhere in the central nervous system.

The purpose of this paper is to demonstrate that injury to optic nerve fibers as far away from the eye as the chiasm results in extensive or complete degeneration of the corresponding retinal ganglion cells. It appears that retrograde degeneration can be more easily demonstrated in the visual system . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Howe Laboratory of Ophthalmology Harvard University Medical School, and the Massachusetts Eye and Ear Infirmary.

Footnotes
Submitted for publication Feb 7, 1963.

This investigation was supported in part by Research Grant B-3483 from the Institute of Neurological Diseases and Blindness, United States Public Health Service, Bethesda, Md, and by a Grant in-Aid No. G-259 from the Bob Hope Fight for Sight Fund of the National Council to Combat Blindness, Inc., New York City.

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