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PETER R. LAIBSON, MD; THEODORE W. SERY, PhD; IRVING H. LEOPOLD, MD

Arch Ophthalmol. 1963;70(1):52-58.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Recently the topical application of an antimetabolite, 5-iodo-2'-deoxyuridine (IDU) has proved efficacious in the treatment of herpes simplex keratitis.¹ Prior to this there was no known chemotherapeutic or antibiotic agent which was capable of inactivating or retarding the herpes simplex virus in vivo in man or animal.

Sery and Furgiuele² had investigated over 150 compounds and found no significant antivirus activity in the treatment of herpes simplex infections in the rabbit cornea despite impressive virus neutralization properties of some in vitro. In past years numerous investigators have tested steroids, antibiotics, and enzymes in experimental animals and man. Antibiotics do not enhance the healing process after infection with herpes simplex, although they do protect against secondary infection.³ Anti-inflammatory steroids alter unfavorably the normal course of corneal herpes simplex infection when applied topically and/or used systemically.^4,5 It has been suggested by clinical and experimental studies that the . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Research and Clinical Departments of the Wills Eye Hospital.

Footnotes
Submitted for publication Nov 1, 1962.

This investigation was supported by grant 2B-5076 from the National Institute of Neurological Diseases and Blindness, National Institutes of Health and by a grant from the Smith, Kline & French Laboratories.

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