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Plasma Cells and Gamma-Globulin in Trabecular Meshwork of Eyes with Primary Open-Angle Glaucoma
BERNARD BECKER, MD;
HANNS-HELLMUTH UNGER, MD;
STAN L. COLEMAN, MD;
EDWIN U. KEATES, MD
Arch Ophthalmol. 1963;70(1):38-41.
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Histologic sections of the trabecular meshwork of eyes with primary open-angle glaucoma have been found to stain for -globulin.1 Plasma cells were also found in the trabecular meshwork of such glaucomatous eyes. An independent careful study of trephine buttons from glaucomatous eyes revealed similar cells.2
This paper reports on the incidence both of -globulin and of plasma cells in a larger series of trephine buttons and eyes from patients with primary chronic open-angle glaucoma.
Material and Methods
Fifty-two trephine buttons* from patients with chronic simple open-angle glaucoma were fixed in neutral formalin or Stieve's solution, embedded in paraffin and sectioned. In addition 28 enucleated or autopsy eyes* with proved chronic simple open-angle glaucoma and 65 routine autopsy eyes were available for study. All specimens included in this study were from patients with bilateral glaucoma and no evidence whatsoever of secondary glaucoma or complicating factors (prior cataract or glaucoma
. . . [Full Text PDF of this Article]
Author Affiliations
St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, and the Department of Ophthalmology, University of Freiburg im Breisgau, Germany, Director: Prof. Dr. W. Wegner.
Footnotes
Submitted for publication Sept. 17, 1962.
This investigation was supported in part by a research grant, B-621, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.
The research relating to this study was also financed in part under a grant to Washington University School of Medicine made by the Alfred P. Sloan Foundation, Inc. The grant was made upon recommendation of the Council for Research in Glaucoma and Allied Diseases. Neither the Foundation nor the Council assumes any responsibility for the published findings in this study.
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