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DICK HOEFNAGEL, MD; MAURICE E. KEENAN, MD; FRED H. ALLEN, JR., MD

Arch Ophthalmol. 1963;69(6):760-764.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Congenital anophthalmia, complete absence of the eyeball, refers to the absence at birth of the structures of the eye derived from the neural ectoderm. In a strict sense true anophthalmia can only be diagnosed after careful histological examination of the entire contents of the orbit demonstrating the complete absence of any rudiments of neuroectodermal structures, because it is possible that the presence of such structures, while clinically not visible or palpable, indicates an extreme degree of microphthalmia. The terms anophthalmia and microphthalmia are therefore often used interchangeably^1,2 or an extreme form of microphthalmia is referred to as pseudoanophthalmia. In the absence of histological verification the terms apparent or clinical anophthalmia are used.

Several reports of single cases of unilateral anophthalmia have been published, and in about half of these cases some other congenital defect has been present in the other eye.³ Familial cases of unilateral anophthalmia have also . . . [Full Text PDF of this Article]

Author Affiliations
Hanover, NH, and Boston

From the Departments of Pathology and Pediatrics, Dartmouth Medical School, Hanover, NH; The Department of Pediatrics, Boston University School of Medicine (Boston City Hospital); and the Blood Grouping Laboratory, Boston.

Footnotes
Submitted for publication Nov 15, 1962.

Supported by USPHS Grant GM 10210 and GM 09107.

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