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II. Inverted Follicular Keratosis

MILTON BONIUK, MD; LORENZ E. ZIMMERMAN, MD

Arch Ophthalmol. 1963;69(6):698-707.

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In 1954 Helwig¹ described a tumor of the skin that occurred mainly on the face. This lesion, which he called inverted follicular keratosis, usually appeared as a solitary papule or nodule projecting from the surface of the skin. He had observed some variable histologic features but described a cellular pattern in which the cells in the central cellular mass ranged from squamoid cells to cells that resembled those located just above the level of the basal cell layer. In the transition between these extremes, squamoid cells formed little clusters, for which he coined the expression "squamous eddies." Helwig indicated that the lesion was benign, although it frequently had been misinterpreted as carcinoma. We, too, have been impressed with the importance of this lesion in the differential diagnosis of malignant neoplasms of the eyelid but feel that it has definite histological features that set it apart from other epithelial tumors . . . [Full Text PDF of this Article]

Author Affiliations
Washington, DC

Chief, Ophthalmic Pathology Branch, and Registrar, Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, D.C. (Dr. Zimmerman).; Assistant Professor of Ophthalmology and Chief, Section of Ophthalmic Pathology, Baylor University College of Medicine, Houston, Texas (Dr. Boniuk).; From the Armed Forces Institute of Pathology, Washington 25, D.C. This work was begun during tenure of a special Fellowship from the National Institute of Neurological Diseases and Blindness, NIH, HEW, awarded to Dr. Boniuk, 1960-1961.

Footnotes
Submitted for publication Oct. 26, 1962.

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