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The Electroretinogram in Albinos and Carriers of the Ocular Albino Trait
ALEX E. KRILL, M.D.;
GILBERT B. LEE, M.A.
Arch Ophthalmol. 1963;69(1):32-38.
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Albinism is a hereditary anomaly of pigmentation caused by the insufficient formation of melanin pigments. There is marked variation in the degree of this insufficiency. In the most severe form the lack of pigmentation is noted throughout the entire body (universal or generalized albinism), and in the mildest form, in the eye alone (ocular albinism).1
The ocular involvement is usually more extensive in the universal albinism, as evidenced by lighter appearance of the fundus, greater photophobia, and lower visual acuity. The ocular involvement may also vary with age. An increase in pigmentation occurs in most albinotic eyes (and in the skin and hair of universal albinos) with advancing age.1 This pigmentary increase is accompanied by a decrease in photophobia and nystagmus and is often characterized by improvement in visual acuity.
The genetic factors include a usual recessive inheritance in universal albinism and an intermediate sex-linked inheritance in the
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
From the Department of Ophthalmic Surgery, University of Michigan, and the Foundation for Ophthalmic Research, The University of Chicago.
Footnotes
Submitted for publication May 31, 1962.
Presented in part at the Midwestern Section of the Association for Research in Ophthalmology, April, 1962, Chicago.
This study was supported in part by United States Public Health Service Grant B-1578.
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