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Homoimmune Uveitis in the Guinea PigI. General Concepts of Auto- and Homoimmunity, Methods, and Manifestations
SAMUEL B. ARONSON, M.D.;
MICHAEL J. HOGAN, M.D.;
PHYLLIS ZWEIGART
Arch Ophthalmol. 1963;69(1):105-109.
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Introduction
Autoimmunity.
—The general concept of autoimmunity probably was first postulated by von Pirquet in 1903.1 This idea was adapted to ocular inflammations by Golowin2 in 1910. Since then, wide experimental applications have been made. One human disease, Hashimoto's thyroiditis,3,4 seems to have supported this hypothesis. Identification of a specific circulating autoantibody in other diseases has not been possible.
The concept of autoinduced disease is based on the theory that a tissue can reject one or a combination of its component parts. Activation occurs through an immune pathway, with elaboration of antibody to the specific antigen. Initially it was believed that such antigens were isolated from the general body mechanisms by a fairly impermeable barrier, such as the position of cells within the lens capsule5 and the intraluminal position of mature sperm.6
Later studies suggested that tissues normally are not antigenic, but somehow are altered,
. . . [Full Text PDF of this Article]
Author Affiliations
San Francisco
Special Fellow, United States Public Health Service (Dr. Aronson).; From the Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California School of Medicine.
Footnotes
Submitted for publication June 25, 1962.
This investigation was supported by United States Public Health Service Grant B-1099.
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