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BERNARD BECKER, M.D.; EDWIN U. KEATES, M.D.; STAN L. COLEMAN, M.D.

Arch Ophthalmol. 1962;68(5):643-647.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The evidence that the elevated intraocular pressure of glaucomatous eyes is associated with increased resistance to outflow of aqueous humor has stimulated careful study of the trabecular meshwork. The histologic changes which have been described in the meshwork of eyes with proved open-angle glaucoma include, among other findings, swelling of trabecular sheets, degeneration and fragmentation of the collagen core, and proliferation of endothelial cells. A consideration of such changes raised the question of glaucoma as a connective tissue disorder.^1-3

The use of fluorescein-labeled antibodies has demonstrated -globulin in many of the connective tissue disorders and suggested immunogenic components of these disease processes.⁴ In the present investigation similar evidence for the presence of -globulin was found in the trabecular meshwork of glaucomatous eyes.

Methods

Material from 25 eyes with chronic open-angle glaucoma was studied. Eighteen eyes were obtained from 16 patients (14 at autopsy and 4 at . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Footnotes
Submitted for publication April 27, 1962.

Read before the Section on Ophthalmology, 111th Annual Meeting of the American Medical Association, Chicago, June 27, 1962.

This investigation was supported in part by a research grant, B-3445, from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service. The research relating to this study was also financed in part under a grant to Washington University School of Medicine made by the Alfred P. Sloan Foundation, Inc. The grant was made upon recommendation of the Council for Research in Glaucoma and Allied Diseases. Neither the Foundation nor the Council assumes any responsibility for the published findings in this study.

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