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A Family History

ROBERT C. DREWS, M.D.

Arch Ophthalmol. 1962;68(3):329-330.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There are several papers in the literature which summarize our present knowledge of the genetic transmission of retinoblastoma.^1-5 Most family trees published are remarkable for their small size. Of particular interest is the finding by Macklin⁴ that with sufficient development of the family history about 10% of so-called sporadic cases are found to have affected collateral lines. The recognition of transmission of retinoblastoma by nonaffected parents remains unusual. Falls and Neel⁵ reported only 1 such kindred in their extensive study (53 families).

Report of Case

I had the opportunity of caring for a 17-month-old negro female who presented with a "cat's-eye" pupillary reflex and an esotropia, both said to have been of 9 months' duration. Examination under anesthesia showed a white, vascularized mass in the posterior pole encroaching on the optic nerve. Enucleation was performed, and the diagnosis of retinoblastoma was confirmed. Invasion of the optic nerve . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine.

Footnotes
Submitted for publication March 12, 1962.

This investigation was performed while the author was stationed at the U.S. Naval Hospital, Great Lakes, Ill.

Opinions or assertions are the private ones of the writer and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

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