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Their Possible Relationship to Diabetic Retinopathy

A. BERKEN, M.D.

Arch Ophthalmol. 1962;67(4):505-510.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The generalized Shwartzman reaction is produced, classically, in rabbits by 2 appropriately-spaced intravenous injections of Gram-negative bacterial endotoxin and is characterized by the precipitation of eosinophilic, periodic acid-Schiff (PAS)-positive material in the vasculature of many organs including kidney, liver, lung, and spleen.^2,3 There often occurs in this reaction glomerular capillary dilatation and the deposition within such capillaries of PAS-positive material.⁴ This finding suggested the possibility of similar dilatations in the retinal capillaries in the generalized Shwartzman reaction.

The appearance of the glomeruli in the generalized Shwartzman reaction (Fig. 1) suggests similarity to that described in the Kimmelstiel-Wilson lesion⁵ (Fig. 2). There is evidence for the coincidence of retinopathy and the Kimmelstiel-Wilson lesion in diabetes mellitus.^6,7 In diabetic retinopathy aneurysmal dilatations are found on both the venous and arterial sides of the capillaries and, less frequently, in small veins. The aneurysms may be mere out-pouchings of the . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Pathology, Government Hospital, Tel Hashomer, Israel.

Present address, Department of Medicine, Bronx Municipal Hospital Center, Bronx 61, N.Y.

A Fight for Sight Research Fellow of the National Council to Combat Blindness, Inc., New York.

Footnotes
Submitted for publication Sept. 6, 1961.

Supported in part by a grant from the National Council to Combat Blindness, Inc., New York.

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