 |
|
Hypophysectomy Effect on Lens Epithelium Mitosis and Galactose Cataract Development in Rats
EDWARD COTLIER, M.D.
Arch Ophthalmol. 1962;67(4):476-482.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Introduction
Endocrine disorders, such as diabetes and hypoparathyroidism, are known to be associated with cataracts in both human and experimental eyes.1-3 The possible effects of other endocrine glands on the lens stimulated the present series of experiments. As a preliminary approach to the problem, the effects of hypophysectomy on the mitosis of the lens epithelium and on the development of galactose cataract in the rat were studied.
The different criteria utilized to evaluate possible alterations in the lens were (1) the number of mitotic cells in the lens epithelium in static conditions and after colchicine administration; (2) biomicroscopic changes; (3) lens transparency, and (4) the level of total plasma-reducing sugar before and after yeast incubation.
Material and Methods
Male albino rats (weight 150 gm. at the beginning of each experiment) were obtained from the Hormone Assay Laboratory (Chicago). Hypophysectomized and control animals were born on the same day and
. . . [Full Text PDF of this Article]
Author Affiliations
St. Louis
From the Department of Ophthalmology, Washington University School of Medicine, and the Oscar Johnson Institute.
Footnotes
Submitted for publication Sept. 4, 1961.
Presented at the 13th meeting of the Midwestern Association for Research in Ophthalmology at Kansas City, Kans., April 29-30, 1961.
This project was supported in part by a Fellowship Grant (F-146) of the Bob Hope Fight for Sight Fund, National Council to Combat Blindness, New York, and in part by a research grant (B-1375) of the National Institute of Neurological Diseases and Blindness, National Institute of Health, U.S.P.H.S.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
