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Transient Increase in Outflow Facility After Superior Cervical Ganglionectomy in Rabbits
ERNST H. BÁRÁNY, M.D.
Arch Ophthalmol. 1962;67(3):303-311.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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The ocular hypotony observed by Linnér and Prijot1 to occur 24 hours after excision of the superior cervical ganglion in rabbits was shown by Langham and Taylor2 and by Sears and Bárány3 to be due to a marked increase in facility of outflow. The phenomenon (henceforth called the ganglionectomy effect) has been tentatively explained by Sears and Bárány as being partly due to the release of a facility-increasing -adrenergic substance from degenerating nerve endings in the eye and partly to a decrease in a facility-decreasing β-adrenergic substance. The present paper reports a number of further experiments regarding this question.
Methods
Technique.
—With unimportant exceptions, the technique used was that employed by Sears and Bárány.3 Briefly, albino rabbits, mainly males, weighing between 2 and 2.5 kg., underwent superior cervical ganglionectomy under a short-acting barbiturate. For measurement of facility and pressure (in the standard experiment 24 hours later)
. . . [Full Text PDF of this Article]
Author Affiliations
Uppsala, Sweden
From the Department of Pharmacology, Uppsala University.
Footnotes
Submitted for publication July 27, 1961.
Supported in part by research grant B-3060 from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service.
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