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Effect of Polymyxin B Sulfate on Pseudomonas Corneal Ulcers
J. WALLACE McMEEL, M.D.;
RONALD M. WOOD, Ph.D.;
LAWRENCE B. SENTERFIT, Sc.D.
Arch Ophthalmol. 1961;66(5):646-648.
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Treatment of Pseudomonas corneal ulcers has been disappointing with encouraging results appearing in the literature only within the past 5 years. Morelli's1 review of the literature up to 1922 shows a story of almost unanimous failure, with 23 enucleations, 14 leukomas, and 1 nebula. Moorman's2 review of 24 cases from 1922 until 1939 showed 12 eyes enucleated, 9 with vision 20/200 or less, and only 3 with vision better that 20/200; whereas 25 cases from 1939 until 1955 treated with sulfa compounds or antibiotics other than polymyxin B sulfate resulted in 10 enucleations, 9 eyes with 20/200 vision or less, and 6 eyes with vision better that 20/200. Of 11 cases treated by Moorman with polymyxin B or E sulfate. one eye was enucleated, 7 had vision 20/200 or less, and 3 had vision better than 20/200. There were 8 cases of corneal ulcer due to Pseudomonas reported
. . . [Full Text PDF of this Article]
Author Affiliations
Baltimore
From the Wilmer Ophthalmological Institute of The Johns Hopkins University and Hospital.
Footnotes
Submitted for publication May 25, 1961.
This work was supported, in part, by Grant B-43, U.S. Public Health Service.
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