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J. REIMER WOLTER, M.D.

Arch Ophthalmol. 1961;66(4):545-551.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Retinoblastomas are rapidly growing malignant tumors of the retina. They arise from the nuclear layers of the retina and are, therefore, neuroectodermal in character. The characteristic growth pattern of the retinoblastomas is that the neuroectodermal tumor cells arrange themselves in lobules around many newly formed vascular channels. These arise from the retinal blood vessels and represent the blood supply of the tumor. In most cases the growth of the fibrovascular stroma of the retinoblastomas cannot keep up with the rapid growth of the tumor cells. Thus, the tumors often "outgrow their own blood supply" despite continuous neovascularization. As a result areas of necrosis and secondary calcification are typically found in the spaces between the lobules of tumor cells arranged around the blood vessels. This is especially common in the most rapidly growing nondifferentiated retinoblastomas without rosettes.

A new technique recently introduced by Kuwabara and Cogan¹ makes it possible for . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich.

Footnotes
Submitted for publication April 10, 1961.

Study supported by Grant No. B-2873 of the U.S. Department of Health, Education, and Welfare.

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