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NINA MORLEY, Ph.D.; CLEMENT McCULLOCH, M.D.

Arch Ophthalmol. 1961;66(3):379-382.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The corneal epithelium has been shown¹ to have an active metabolism that requires more oxygen than is provided by the aqueous humor and the limbal capillaries.² Under normal conditions, the cornea utilizes atmospheric oxygen.^3,4 Experimental limitation of this source of oxygen in the rabbit cornea has resulted in turbidity, swelling, and increased content of lactic acid and water.^5,6 These same effects, produced in human subjects, rabbits, and guinea pigs by wearing contact lenses,^6-8 are attributed to the interruption of the aerobic metabolism of the active epithelial cells upon which both epithelium and stroma appear dependent for energy for carbohydrate breakdown.⁹

A recently developed method for measuring lactic acid and oxidized pyridine nucleotides in the same extracts of tissue from the individual cornea¹⁰ has been used in this case to study the metabolism of the corneal epithelium and stroma of rabbits wearing contact lenses . . . [Full Text PDF of this Article]

Author Affiliations
Toronto, Canada

From the Department of Ophthalmology, Faculty of Medicine, University of Toronto.

Footnotes
Submitted for publication April 12, 1961.

This study was supported by a grant from the Department of National Health and Welfare, Ottawa, Ontario, Canada.

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