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IV. Diabetic Retinopathy

DAVID G. COGAN, M.D.; DANIEL TOUSSAINT, M.D.; TOICHIRO KUWABARA, M.D.

Arch Ophthalmol. 1961;66(3):366-378.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is generally held that microaneurysms constitute the characteristic lesion of diabetic retinopathy. First observed by MacKenzie and Nettleship in 1879,¹ the microaneurysms were rediscovered by Ballantyne and Loewenstein in 1943² and have been described by numerous clinicians and pathologists since that time. Noteworthy has been the predominant localization of the diabetic microaneurysms in the central and paracentral regions, their random distribution, and their association with punctate hemorrhages and "exudates" in the deep retina. It has also been assumed that the microaneurysms and other evidence of angiopathy in diabetic retinas have a bearing on the glomerular changes in diabetic nephropathy^3-5 and that a clarification of the one might yield useful information for the other.

As must be evident from the many reviews which have appeared in recent years,^6-12 the pathogenesis of retinal microaneurysms has been a subject of wide speculation based on some firm evidence but . . . [Full Text PDF of this Article]

Author Affiliations
Boston

Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary.

NATO Fellow (Dr. Toussaint).

Footnotes
Submitted for publication March 26, 1961.

This investigation was supported by a U.S. Public Health Service Research Grant H-4051 from the National Heart Institute, U.S. Public Health Service and a gift for Studies Pertinent to the Ocular Effects of Diabetes.

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