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DAVID PATON, M.D.

Arch Ophthalmol. 1961;66(1):90-94.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The purpose of this paper is to report a characteristic appearance of the bulbar conjunctival circulation as a reliable sign in the diagnosis of clinically significant sickle-cell disease. Although general physical examination can offer many clues, it is proposed here that no other clinical observation establishes that diagnosis with as much certainty. Even routine laboratory tests are occasionally inconclusive, for sickled red blood cells are found in patients with the asymptomatic sickle-cell trait.

In 1957, Goodman, von Sallmann, and Holland¹ described for the first time vascular loops and segments which were found near the limbus in several patients with heterozygous sickle-cell disease. Bulbar conjunctival changes have since been commented on by Lieb, Geeraets, and Guerry² in their monograph on sickle-cell retinopathy. In that report, the following conjunctival abnormalities were noted: icterus, telangiectasis, vascular stasis, and sausagelike dilatations. Their observations indicated a rather low incidence: Of 51 patients with . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Wilmer Ophthalmological Institute, The Johns Hopkins Hospital.

Footnotes
Submitted for publication June 13, 1960.

This paper was presented at the Wilmer Residents Meeting, April, 1960.

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