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ISADORE GIVNER, M.D.

Arch Ophthalmol. 1961;66(1):64.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The following case report is submitted because no similar case could be found in the literature. It is conceivable that given a patient with diabetic retinopathy one might attribute the loss of vision to the retinal pathology—whereas an additional cause such as toxic amblyopia from medication might be at fault.

Chlorpropamide (Diabenese*) is an arylsulfonylurea. It is 1-propyl-3-(p-chlorobenzenesulfonyl) urea, with a molecular weight of 276.76 and an empirical formula of C₁₀H₁₃CIN₂O₃S. It is a sulfonamide, It is rapidly absorbed from the gastrointestinal tract of man.

The side-effects of chlorpropamide include severe hypoglycemia and jaundice. The latter is associated with a skin rash and occurs within 2 to 5 weeks of the initiation of therapy. It is characterized by an elevation of the serum alkaline phosphatase. Leukopenia, eosinophilia, lymphocytosis, and decrease in blood platelets may occur.

Chlorpropamide has produced bizarre neurologic . . . [Full Text PDF of this Article]

Author Affiliations
New York

Footnotes
Submitted for publication May 26, 1960.

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