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CALVIN HANNA, Ph.D.; JAMES E. O'BRIEN, Ph.D.

Arch Ophthalmol. 1961;66(1):103-107.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The epithelial layer of the lens has been implicated in the pathogenesis of several types of cataract.¹ These types, which are progressive, slow to develop, and usually nonreversible, include various radiation cataracts such as those caused by ultraviolet, infrared, x-ray, -ray, neutron, β-ray, and radiomimetic agents such as busulfan (Myleran).* In a number of animal experiments where the germinative zone of the lens epithelium was selectively irradiated a slow forming opacity was found, whereas selective irradiation in other areas of the lens required much larger doses to produce the same effect.^2-4 These results give strong support to the idea that the lens epithelial cells, especially those cells of the proliferative zone, are directly involved in the developing opacity. The sequence of postulated events leading to the formation of radiation cataracts as first suggested by Rohrschneider² and outlined in a book by Duke-Elder⁵ are as follows: "The . . . [Full Text PDF of this Article]

Author Affiliations
Burlington, Vt.

Department of Pharmacology, University of Vermont College of Medicine.

Footnotes
Submitted for publication March 18, 1961.

This study was supported in part by funds made available by a Senior Research Fellowship SF-156 (Dr. Hanna) from the U.S. Public Health Service and by a Grant-in-Aid from the Bob Hope Fight for Sight Fund of the National Council to Combat Blindness, Inc., New York City.

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