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Late Clouding of Experimental Corneal Grafts
E. NELKEN, M.D.;
D. NELKEN, M.D.;
I. C. MICHAELSON, F.R.F.P.S.G., D.O.M.S., Ph.D., M.D.;
J. GUREVITCH, M.D.
Arch Ophthalmol. 1961;65(4):584-590.
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Introduction
It has been shown that homograft rejection in general and late clouding of corneal grafts in particular are immunologic processes.1,2 Some of the characteristics of the so-called tissue antigens have been defined, but their exact nature is not yet known.3,4
ABO antigens in the human cornea corresponding to those of the red blood cells have been demonstrated by us.5 It was also found that the isoantibody titer rose in the serum of several patients receiving corneal grafts incompatible with their blood group.6-8 These 2 findings stimulated the question as to whether the red cell antigens in the donor cornea are capable of causing late clouding of corneal grafts.
The following is a report of experimental perforating keratoplasty in rabbits in which the disease of the graft could be produced by blood group incompatibility between the donor and recipient.
Materials and Methods
Selection of Rabbits.
—Wild
. . . [Full Text PDF of this Article]
Author Affiliations
Jerusalem, Israel
Department of Ophthalmology, Hadassah University Hospital (Drs. E. Nelken and Michaelson). Department of Clinical Microbiology, Hebrew University, Hadassah Medical School (Drs. D. Nelken and Gurevitch).
Footnotes
Submitted for publication Nov. 17, 1960.
This study has been aided by Grant No. B-2018 from the U.S. Public Health Service, National Institutes of Health.
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