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KEVIN HILL, M.D.; JEREMY B. WHITNEY, M.D.; ROBERT R. TROTTER, M.D.

Arch Ophthalmol. 1961;65(4):497-503.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical use of urea as an ocular hypotensive agent has only recently been reported in the ophthalmic literature although its effect upon the intraocular pressure was demonstrated experimentally over 45 years ago. In 1914, Hertel¹ reported that the intraocular pressure of rabbits was lowered by a 20% solution of urea injected intravenously. Subsequently, Fremont-Smith and Forbes² noted reduction of intracranial and intraocular pressure of cats after the intraperitoneal injection of hypertonic urea solutions, but little or no clinical application of these observations was made until Javid and Settlage³ emphasized the effectiveness of hypertonic urea solutions in lowering cerebrospinal fluid pressure in neurosurgical patients.

Bunge et al.⁴ studied the effect of urea upon the intraocular pressure of monkeys; Javid⁵ noted that the intraocular pressure of human subjects could be reduced by urea injected intravenously. However, it remained for Galin, Aizawa, and McLean^6,7,8 to demonstrate . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Massachusetts Eye and Ear Infirmary.

Footnotes
Submitted for publication Dec. 22, 1960.

Supported in part by the E. B. Dunphy Testimonial Fund.

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