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Part IV

SIDNEY LERMAN, M.D.

Arch Ophthalmol. 1961;65(3):334-337.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Previous communications have reported on certain biochemical changes that occur in the lenses of young rats (aged 28-32 days) maintained on a cataractogenic galactose diet.^1-3 The accumulation of galactose-1-phosphate in these lenses apparently acts as or gives rise to an inhibitor of the enzyme glucose-6-phosphate dehydrogenase (G-6-P-D) during the first few days that these animals are maintained on a high galactose diet.¹ The hexose monophosphate shunt is concurrently impaired as evidenced by a marked fall in the C₁/C₆ ratio of C¹⁴O₂ recovered from these lenses incubated with glucose labeled in the number 1 or number 6 carbon atom.² The concentration of high energy phosphate (ATP) in these lenses also decreases after the animals have been maintained on the diet for 3 days.

In order to further elucidate some of these changes that occur within the lens under the cataractogenic influence of . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, N.Y.

From the Department of Surgery, Division of Ophthalmology of the University of Rochester School of Medicine and Dentistry.

Footnotes
Submitted for publication July 1, 1960.

This work was supported by research funds granted by the Rochester Eye Bank and Research Society, Inc.

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