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Brushfield's Spots

DAVID D. DONALDSON, M.D.

Arch Ophthalmol. 1961;65(1):26-31.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Spots on the iris associated with mongolism have been described for more than 30 years. Similar spots were described on the irides of normal individuals some 50 years ago. Nevertheless the spots occurring in mongolism do not appear to have been subjected to a systematic comparison with those in normal irides. This relationship would seem to have some practical value in that the early diagnosis of mongolism is often in doubt.

In 1902 Wolfflin¹ described elevated nodules which were usually situated in the periphery of the iris. Occurring in about 10% of all normal individuals, the color of the nodules was whitish or light yellow, and there were 10 to 20 per eye. They were similar in both eyes of the same individual and were seen about 10 times as often in blue as in brown irides. In . . . [Full Text PDF of this Article]

Author Affiliations
Boston

Howe Laboratory of Ophthalmology, Harvard University Medical School.

Footnotes
Submitted for publication Aug. 24, 1960.

This work supported in part by research grant No. B-1851, National Institute of Neurological Diseases and Blindness.

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